(205) 271-4100

Mesothelioma Hotline
We're here for you every step of the way.

What Are the Treatment Options for Mesothelioma?

Mesothelioma, or any cancer, is a life-altering diagnosis. With only 3,300 diagnosed cases a year, it is unlikely that you know someone who has gone through treatment for mesothelioma before. Luckily, there are dozens of sources to learn more about what treatments are available and how they work. Familiarize yourself with your treatment options before heading to your next doctor’s appointment so that you can have a thoughtful conversation and figure out what is best for you or your loved one.

There are many mesothelioma treatment options that can significantly prolong life expectancy and improve quality of life. Your treatment options will depend on a number of factors, including the type of mesothelioma you’ve been diagnosed with (usually pleural, peritoneal, or pericardial), the cell type present in the tumors (epithelioid, sarcomatoid, or biphasic), and the stage (1–4). Your demographics (sex, age) and your overall health will also impact your options and prognosis.

Patients diagnosed at stages 1 or 2 are sometimes candidates for curative treatment options that aim to remove as much of the cancer as possible. Because curative treatments can be aggressive — often involving a combination of surgery, chemotherapy, and radiation — they are usually only recommended for patients who are otherwise in good health. For later-stage patients and those who are not in good health, doctors generally focus on palliative care to relieve pain and discomfort and mitigate symptoms (such as breathing difficulties).

Phases of Mesothelioma Treatment

Doctors tailor treatment plans to the individual patient, but most mesothelioma patients pursue multimodal therapy, which involves a combination of treatment types. This often involves a three-step process (also known as trimodal therapy) of neoadjuvant therapy, primary therapy, and adjuvant therapy.

Neoadjuvant therapy

Neoadjuvant therapy refers to procedures that take place before primary treatment. These kinds of therapies are typically meant to be done before surgery as a way to shrink tumors or stop the spread of the cancer. There are multiple therapies that can be employed before someone’s primary treatment, but neoadjuvant therapy for mesothelioma often includes radiation and/or chemotherapy.

Primary therapy

Just as it sounds, primary therapy is the main treatment or treatments employed to treat an illness. An oncologist or mesothelioma surgeon will advise the best options for the individual patient based on their specific case. This can be one or a combination of several therapies. The primary therapy for mesothelioma is usually surgery to remove cancerous tumors. The primary therapy for peritoneal mesothelioma often includes heated chemotherapy administered during surgery.

Adjuvant therapy

Adjuvant therapy occurs after the primary therapy is over. Typically, adjuvant therapies like chemotherapy or radiation are done after surgery to improve the results, prevent recurrence, or relieve pain or symptoms that may have been caused by either the cancer or the treatment itself.

Mesothelioma Treatment Options

There are multiple treatment options for mesothelioma, including surgery, chemotherapy, radiation, and immunotherapy, as well as clinical trials to test emerging treatments. Doctors also employ palliative care to relieve symptoms and improve the patient’s quality of life.

This picture shows two doctors about to perform surgery on a mesothelioma patient.


Surgery for mesothelioma is usually performed as a curative, primary treatment. Depending on the type and stage of mesothelioma, the surgeon will attempt to remove as much of the tumor as possible. They may also remove parts of the affected organs. This is resectable mesothelioma. In cases of unresectable mesothelioma, less-invasive surgical procedures may be used as palliative treatments, helping to ease pain or discomfort caused by mesothelioma. Learn more about mesothelioma surgery.

This picture shows a doctor administering chemo therapy to a mesothelioma patient.


Chemotherapy is one of the better-known treatments for cancer. After someone has been diagnosed with mesothelioma, chemotherapy drugs may be administered as a neoadjuvant therapy to shrink any tumors present to make surgery easier or to avoid surgery altogether. Chemotherapy may also be implemented after surgery to eradicate any remaining mesothelioma cancer cells. Your mesothelioma doctor may also use chemotherapy as a palliative to slow the spread of the cancer and extend your life expectancy. Learn more about chemotherapy for mesothelioma.

This picture shows two doctors about to administer radiation as a treatment to a mesothelioma patient.


Radiation oncologists use targeted, high-energy particle beams to shrink or eradicate cancer cells and prevent them from spreading throughout the body. This form of therapy can be used alone or as a neoadjuvant treatment, though it is primarily used after surgery or the primary therapy as an adjuvant therapy. Radiation can also be a part of palliative care to help reduce the symptoms of mesothelioma. Learn more about radiation therapy for mesothelioma.

This is a picture of a doctor administering immunotherapy to a mesothelioma patient.


Immunotherapy is becoming increasingly common in the treatment of mesothelioma. Also called biotherapy, immunotherapy enhances the body’s own immune system to help it fight the spread or recurrence of mesothelioma. This treatment is generally reserved for patients whose mesothelioma continues to spread after they’ve already been through chemotherapy. Although it is still being tested, immunotherapy is an established emerging treatment for mesothelioma and has had some promising results. This is good news for patients, since it is less harsh on the body that many other cancer treatments. Learn more about immunotherapy for mesothelioma.

This image shows two doctors performing clinical trials and brainstorming for further treatment options.

Clinical Trials and Emerging Treatments

As technology advances, new clinical trials and emerging treatments become available. Many mesothelioma patients are candidates for clinical trials. These may involve access to emerging or new versions of current treatments, such as chemotherapy drugs or types of immunotherapy. Many of the new treatments and medications being developed for mesothelioma care cause fewer and less-harmful side effects. Clinical trials and emerging treatments are usually part of a multimodal plan. They can come before or after standard therapies such as surgery, chemotherapy, and radiation. As more data is collected, some of these experimental treatments may become part of the standard treatment program. That’s why clinical trials for mesothelioma are so important. Learn more about clinical trials for mesothelioma.

Mesothelioma Treatment - Palliative Care

Palliative Care

This form of care relieves pain and discomfort caused by the disease and its accompanying symptoms. Palliative care is not intended to be curative, but it can be combined with curative treatment to provide relief from both the symptoms of mesothelioma and the side effects of therapy. It is typical for a mesothelioma patient’s medical team to include palliative care as a way to ease some of the side effects of their primary treatment. This can include removing fluid via pleurodesis, shunt placement, or catheter placement. Learn more about palliative care for mesothelioma.

Cancer Care and Mesothelioma Treatment Specialists

This image shows a cancer care team discussing mesothelioma among themselves.Because mesothelioma is so rare, you should consider working with a doctor who specializes in treating this type of cancer. Together, you will be able to craft a custom treatment plan. Find mesothelioma specialists and treatment centers in your area.

You’ll also interact with many other health care professionals, from nurses to surgeons to mental health workers. This is your cancer care team. Dealing with so many doctors can be confusing, but becoming familiar with each specialist can make everything a bit less scary. Need help? Meet the rest of your cancer care team.

This picture shows a doctor explaining to a patient how to improve their mesothelioma prognosis.

Improving Your Prognosis

While it may seem like there is little to be done outside of doctor-administered therapy, working on physical health can improve the way the body responds to treatment. Regular exercise and changes to diet are the two biggest ways to affect this. Learn how simple lifestyle changes can improve your mesothelioma prognosis.

Affording Mesothelioma Treatment

A common concern among anyone who has been diagnosed with cancer is how to afford treatment. People suffering from mesothelioma are no different. What sets mesothelioma cases apart from other cancer diagnoses is that there is often legal action that can be taken. This can result in compensation that may pay for all of some of the treatment. If you or a loved one have been diagnosed with mesothelioma and you are trying to figure out your options, reach out to a lawyer that specializes in mesothelioma cases or get a free case evaluation.

Mesothelioma Hotline

Mesothelioma Hub is dedicated to helping you find information, support, and advice. Reach out any time!

Mesothelioma Hotline

We’re here for you every step of the way.

(205) 271-4100