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Mesothelioma Hotline
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Mesothelioma is known to have a long latency period. This means that the time between initial asbestos exposure and the onset of symptoms is delayed, sometimes upwards of 50 years. This is why most patients are diagnosed with the disease at later stages. It’s not until the cancer begins to advance that symptoms become severe enough that a patient sees a doctor.

When diagnosed at stage 4, mesothelioma is no longer localized and has begun spreading throughout the body. Symptoms are typically the most intense at this stage. While limited, palliative treatment can still be an option for managing stage 4 mesothelioma and keeping patients comfortable.

Stage 4 Mesothelioma by Type

Stage 4 pleural mesothelioma

Pleural mesothelioma is the most common form of the disease, affecting the pleura (lining of the lungs and chest). Pleural mesothelioma is the only form with a defined staging system.

Of the three staging systems — the Brigham, the Butchart, and the TNM — the TNM staging system has become the go-to for doctors when staging mesothelioma. It evaluates the extent and location of the tumors (T), lymph node involvement (N), and metastasis (M) or spread of the cancer.

At stage 4, the cancer has metastasized throughout the body, reaching distant organs. Resective surgery to remove the cancer is no longer an option, however, there are treatment options available to improve the quality of life while living with mesothelioma.

The TNM scale categorizes stage 4 mesothelioma as:

Stage 4

  • The primary tumor is no longer resectable (able to be removed via surgery)
  • Spread is no longer localized and has reached the lymphatic system
  • Distant spread to other organs

Stage 4 peritoneal mesothelioma

Peritoneal mesothelioma occurs in the abdomen and is a very rare condition. As a result, there is no defined staging system for this form of the disease.

Mesothelioma doctors often rely on the Peritoneal Cancer Index (PCI) for staging peritoneal mesothelioma. It measures the extent of metastasis and provides a score between 0 and 39, with higher scores representing more aggressive cancers. Stage 4 patients usually have a high PCI score, indicating a likely terminal cancer. At this stage, there is extensive spread throughout the body, and a viable treatment plan is likely limited to palliative care to lessen symptoms and offer pain relief.

Stage 4 pericardial mesothelioma

The rarest form of mesothelioma, pericardial mesothelioma, targets the lining of the heart. As with peritoneal mesothelioma, there is no established staging system. Doctors can look to the American Joint Committee on Cancer (AJCC) 1 through 4 scale, however, the pericardial form is often not diagnosed until advanced stages or after the patient has passed away.

Symptoms of Stage 4 Mesothelioma  

When diagnosed at stage 4, mesothelioma patients experience worsening symptoms. Symptoms will vary based on where the cancer is located in the body. Treatment options may be available to relieve symptoms and improve the patient’s quality of life.
Mesothelioma Hub - Stage 4 Symptoms
Stage 4 Mesothelioma Symptoms

  • Abdominal or chest pain
  • Anemia
  • Chronic fatigue
  • Coughing up blood (hemoptysis)
  • Difficulty swallowing (dysphagia)
  • Fluid buildup in the abdomen or chest
  • Night sweats
  • Shortness of breath (dyspnea)
  • Pain or tightness in the chest
  • Severe weight loss

Stage 4 Mesothelioma Survival Rates

Unfortunately, stage 4 mesothelioma carries the poorest prognosis. Patients diagnosed at this stage usually have a life expectancy of around a year. There are many support resources available to help patients and their families through this difficult time.

It’s also important to keep in mind that each mesothelioma case is different. Palliative care may be available to extend a patient’s life expectancy, and patients have exceeded their original prognoses.

Treating Stage 4 Mesothelioma

If you or a loved one has experienced mesothelioma symptoms or has received a diagnosis, it’s important to seek out a second opinion. Mesothelioma is a very rare form of cancer. A specialist will be able to provide an accurate diagnosis and help you decide on a tailored treatment plan.

Treatment options are largely dependent on patient health. Surgery, chemotherapy, radiation, immunotherapy, and clinical trials may all still be available to stage 4 patients as a form of cancer and pain management.

Find a mesothelioma specialist using the Mesothelioma Hub doctor directory.

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Mesothelioma Hotline

We’re here for you every step of the way.

(205) 271-4100