What is Tremelimumab?
Tremelimumab is an immunotherapy drug that helps the immune system block cancerous cells. The pharmaceutical companies Pfizer and Medarex licensed and patented the drug in 2004. Since then, multiple studies have tested the drug on several types of cancer.
Tremelimumab, which has no brand name yet, has not been approved by the United States Food and Drug Administration (FDA) to treat any cancer or disease. The medication was first studied as a treatment for metastatic melanoma. Further research has been done to test the drug as a treatment for metastatic renal cell carcinoma, malignant pleural mesothelioma, metastatic colorectal cancer, and advanced gastric and esophageal adenocarcinoma.
Initial early phase studies of the drug often showed promising results, in which the drug stopped tumors from growing for periods of time. Clinical trials often combine the medication with another immunotherapy drug called durvalumab.
The FDA designated the drug as an orphan drug in April 2015. Orphan designation does not guarantee the drug is safe or effective and does not mean the FDA will approve it. An orphan drug typically treats uncommon illnesses, and cannot make much of a profit.
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How Tremelimumab Works
Tremelimumab is a monoclonal antibody drug, which is a type of treatment that helps the immune system fight cancer. Antibodies are proteins produced by plasma cells that the immune system by attaching themselves to molecules on the surface of problematic cells.
Once an antibody attaches to an antigen on a molecule, receptors signal the immune system to fight back. Receptors interpret and respond to signals from multiple factors, such as cancerous cells. The purpose of tremelimumab is to blog receptors on immune cells that normally suppress immune attacks.
Tremelimumab succeeds by activating immune cells, called cytotoxic T lymphocytes (CTLs), or killer T cells, which kill cancer cells. Medications like tremelimumab are designed to fight cancer cells by increasing the amount of activated killer T cells.
Multiple clinical trials have found that the medication works for a short time by stopping cancer growth. After several months, the drug seems to stop working altogether, which is why the FDA hasn’t improved it.
Tremelimumab Side Effects
Previous studies have shown both mild and serious side effects in mesothelioma patients who receive tremelimumab as treatment.
Common side effects include:
- Liver disease
- Nerve inflammation
- Skin rash
Less-common side effects include:
- Holes in the intestines
- Hypothalamus disorders
- Inflammation of the colon
- Obstruction of the small intestine
- Pituitary disorders
- Skin ulcers
- Thyroid disorders
Patients taking the medication can receive medications or therapies to treat each side effect or keep them under control.
Clinical trials on tremelimumab have been conducted on cancer patients in an attempt to study the prevention, detection, or treatment of multiple diseases. While smaller trials have shown success, more research on the drug is needed to treat future patients.
Randomized, Double-blind Study Comparing Tremelimumab to Placebo in Subjects With Unresectable Malignant Mesothelioma
A study called DETERMINE assesses tremelimumab as a second or third-line treatment for malignant mesothelioma patients who ineligible for tumor-removing surgery. Early results in the Phase 2b study have suggested that the drug fails to improve lifespan. Researchers estimate the study will be completed in late 2019. Find more details about the study at ClinicalTrials.gov.
A Phase 2 Study of Durvalumab in Combination With Tremelimumab in Malignant Pleural Mesothelioma
This phase 2 trial conducted by the Dana-Farber Cancer Institute studies how well durvalumab with or without tremelimumab works in treating pleural mesothelioma patients who are eligible for tumor-removing surgery. Both durvalumab and tremelimumab have been tested for mesothelioma alone, but not in combination. The trial was suspended in late 2019 after criteria were not met, but researchers estimate completion in 2024. Details of the clinical study can be found at ClinicalTrials.gov.
MEDI4736 Or MEDI4736 + Tremelimumab In Surgically Resectable Malignant Pleural Mesothelioma
Study participants with malignant pleural mesothelioma either received MEDI4736, known as durvalumab, or durvalumab and tremelimumab in this phase 2 trial. The study concluded is estimated to be completed in late 2019. Researchers suggest that both medications in combination may interfere with the ability of malignant tumor cells to grow and spread. Information about the clinical trial can be found at ClinicalTrials.gov.
To find out more about tremelimumab, talk to your doctor. Multiple treatment options are available to mesothelioma patients. To learn more about treatment, download our free guide.
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